Population Pharmacokinetics of Intravenous Polymyxin B from Clinical Samples.
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ABSTRACT:
SUBMITTER: Kubin CJ
PROVIDER: S-EPMC5826116 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Population Pharmacokinetics of Intravenous Polymyxin B from Clinical Samples.
Kubin Christine J CJ Nelson Brian C BC Miglis Cristina C Scheetz Marc H MH Rhodes Nathaniel J NJ Avedissian Sean N SN Cremers Serge S Yin Michael T MT
Antimicrobial agents and chemotherapy 20180223 3
A retrospective study was conducted in hospitalized patients receiving intravenous polymyxin B who underwent therapeutic drug monitoring during treatment. The aim of this study was to assess the population pharmacokinetics (PK) of intravenous polymyxin B in patients with variable total body weights and create a population model for clinical use. Nonlinear mixed-effects modeling analyses were performed. A total of 43 patients were included, and 70% of these patients were male. The median age was ...[more]
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