Ontology highlight
ABSTRACT:
SUBMITTER: Dijkstra JA
PROVIDER: S-EPMC5826127 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Dijkstra J A JA van der Laan T T Akkerman O W OW Bolhuis M S MS de Lange W C M WCM Kosterink J G W JGW van der Werf T S TS Alffenaar J W C JWC van Soolingen D D
Antimicrobial agents and chemotherapy 20180223 3
Amikacin, kanamycin, and capreomycin are among the most important second-line drugs for multidrug-resistant tuberculosis. Although amikacin and kanamycin are administered at the same dose and show the same pharmacokinetics, they have different WHO breakpoints, suggesting that the two drugs have different MICs. The aim of this study was to investigate possible differences in MICs between the aminoglycosides and capreomycin. Using the direct concentration method, a range of concentrations of amika ...[more]