Ontology highlight
ABSTRACT:
SUBMITTER: Gluck S
PROVIDER: S-EPMC5826565 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Glück Selene S Guey Baptiste B Gulen Muhammet Fatih MF Wolter Katharina K Kang Tae-Won TW Schmacke Niklas Arndt NA Bridgeman Anne A Rehwinkel Jan J Zender Lars L Ablasser Andrea A
Nature cell biology 20170731 9
Cellular senescence is triggered by various distinct stresses and characterized by a permanent cell cycle arrest. Senescent cells secrete a variety of inflammatory factors, collectively referred to as the senescence-associated secretory phenotype (SASP). The mechanism(s) underlying the regulation of the SASP remains incompletely understood. Here we define a role for innate DNA sensing in the regulation of senescence and the SASP. We find that cyclic GMP-AMP synthase (cGAS) recognizes cytosolic c ...[more]