Ontology highlight
ABSTRACT:
SUBMITTER: Nicolaou KC
PROVIDER: S-EPMC5826612 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nicolaou K C KC Pulukuri Kiran Kumar KK Rigol Stephan S Buchman Marek M Shah Akshay A AA Cen Nicholas N McCurry Megan D MD Beabout Kathryn K Shamoo Yousif Y
Journal of the American Chemical Society 20171024 44
An improved and enantioselective total synthesis of antibiotic CJ-16,264 through a practical kinetic resolution and an iodolactonization reaction to form the iodo pyrrolizidinone fragment of the molecule is described. A series of racemic and enantiopure analogues of CJ-16,264 was designed and synthesized through the developed synthetic technologies and tested against drug-resistant bacterial strains. These studies led to interesting structure-activity relationships and the identification of a nu ...[more]