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Human CD4+ CD25+ CD127hi cells and the Th1/Th2 phenotype.


ABSTRACT: CD4+ T cells that co-express CD25 and CD127 (CD25+CD127+) make up around 20% of all circulating CD4+ memory T cells in healthy people. The clinical significance of these cells is that in children with type 1 diabetes their relative frequency at diagnosis is significantly and directly correlated with rate of disease progression. The purpose of this study was to further characterize the CD25+CD127hi cells. We show that they are a mix of Th1 and Th2 cells however, they have a significantly higher relative frequency of pre-committed and committed Th2 cells, and secrete significantly higher levels of Th2-type cytokines than CD25- memory T cells. Further, these cells are neither exhausted nor senescent and proliferate to the same extent as CD25- memory cells. Thus, CD25+CD127hi cells are a highly active subset of memory T cells that might play a role in controlling inflammation via anti-inflammatory Th2-type deviation.

SUBMITTER: Narsale A 

PROVIDER: S-EPMC5826897 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Human CD4<sup>+</sup> CD25<sup>+</sup> CD127<sup>hi</sup> cells and the Th1/Th2 phenotype.

Narsale Aditi A   Moya Rosita R   Davies Joanna Davida JD  

Clinical immunology (Orlando, Fla.) 20180110


CD4<sup>+</sup> T cells that co-express CD25 and CD127 (CD25<sup>+</sup>CD127<sup>+</sup>) make up around 20% of all circulating CD4<sup>+</sup> memory T cells in healthy people. The clinical significance of these cells is that in children with type 1 diabetes their relative frequency at diagnosis is significantly and directly correlated with rate of disease progression. The purpose of this study was to further characterize the CD25<sup>+</sup>CD127<sup>hi</sup> cells. We show that they are a mi  ...[more]

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