Ontology highlight
ABSTRACT:
SUBMITTER: Narsale A
PROVIDER: S-EPMC5826897 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Narsale Aditi A Moya Rosita R Davies Joanna Davida JD
Clinical immunology (Orlando, Fla.) 20180110
CD4<sup>+</sup> T cells that co-express CD25 and CD127 (CD25<sup>+</sup>CD127<sup>+</sup>) make up around 20% of all circulating CD4<sup>+</sup> memory T cells in healthy people. The clinical significance of these cells is that in children with type 1 diabetes their relative frequency at diagnosis is significantly and directly correlated with rate of disease progression. The purpose of this study was to further characterize the CD25<sup>+</sup>CD127<sup>hi</sup> cells. We show that they are a mi ...[more]