Ontology highlight
ABSTRACT:
SUBMITTER: Morimoto T
PROVIDER: S-EPMC5827518 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Morimoto Takaaki T Enmi Jun-Ichiro JI Hattori Yorito Y Iguchi Satoshi S Saito Satoshi S Harada Kouji H KH Okuda Hiroko H Mineharu Yohei Y Takagi Yasushi Y Youssefian Shohab S Iida Hidehiro H Miyamoto Susumu S Ihara Masafumi M Kobayashi Hatasu H Koizumi Akio A
Scientific reports 20180226 1
RNF213 is a susceptibility gene for moyamoya disease, yet its exact functions remain unclear. To evaluate the role of RNF213 in adaptation of cerebral blood flow (CBF) under cerebral hypoperfusion, we performed bilateral common carotid artery stenosis surgery using external microcoils on Rnf213 knockout (KO) and vascular endothelial cell-specific Rnf213 mutant (human p.R4810K orthologue) transgenic (EC-Tg) mice. Temporal CBF changes were measured by arterial spin-labelling magnetic resonance ima ...[more]