Ontology highlight
ABSTRACT:
SUBMITTER: Santana Machado T
PROVIDER: S-EPMC5827590 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Santana Machado Tacy T Poitevin Stéphane S Paul Pascale P McKay Nathalie N Jourde-Chiche Noémie N Legris Tristan T Mouly-Bandini Annick A Dignat-George Françoise F Brunet Philippe P Masereeuw Rosalinde R Masereeuw Rosalinde R Burtey Stéphane S Cerini Claire C
Journal of the American Society of Nephrology : JASN 20171208 3
In patients with CKD, not only renal but also, nonrenal clearance of drugs is altered. Uremic toxins could modify the expression and/or activity of drug transporters in the liver. We tested whether the uremic toxin indoxyl sulfate (IS), an endogenous ligand of the transcription factor aryl hydrocarbon receptor, could change the expression of the following liver transporters involved in drug clearance: <i>SLC10A1</i>, <i>SLC22A1</i>, <i>SLC22A7</i>, <i>SLC47A1</i>, <i>SLCO1B1</i>, <i>SLCO1B3</i>, ...[more]