Ontology highlight
ABSTRACT:
SUBMITTER: Bitok JK
PROVIDER: S-EPMC5827622 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Bitok J Kipchirchir JK Lemetre Christophe C Ternei Melinda A MA Brady Sean F SF
FEMS microbiology letters 20170901 16
The majority of environmental bacteria are not readily cultured in the lab, leaving the natural products they make inaccessible using culture-dependent discovery methods. Cloning and heterologous expression of DNA extracted from environmental samples (environmental DNA, eDNA) provides a means of circumventing this discovery bottleneck. To facilitate the identification of clones containing biosynthetic gene clusters, we developed a model heterologous expression reporter strain Streptomyces albus: ...[more]