Bumetanide for autism: more eye contact, less amygdala activation.
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ABSTRACT:
SUBMITTER: Hadjikhani N
PROVIDER: S-EPMC5827728 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Bumetanide for autism: more eye contact, less amygdala activation.
Hadjikhani Nouchine N Åsberg Johnels Jakob J Lassalle Amandine A Zürcher Nicole R NR Hippolyte Loyse L Gillberg Christopher C Lemonnier Eric E Ben-Ari Yehezkel Y
Scientific reports 20180226 1
We recently showed that constraining eye contact leads to exaggerated increase of amygdala activation in autism. Here, in a proof of concept pilot study, we demonstrate that administration of bumetanide (a NKCC1 chloride importer antagonist that restores GABAergic inhibition) normalizes the level of amygdala activation during constrained eye contact with dynamic emotional face stimuli in autism. In addition, eye-tracking data reveal that bumetanide administration increases the time spent in spon ...[more]
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