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Clinical Utility of FDG PET/CT in Patients with Autoimmune Pancreatitis: a Case-Control Study.


ABSTRACT: Autoimmune pancreatitis (AIP) shares overlapping clinical features with pancreatic cancer (PC). Importantly, treatment of the two conditions is different. We investigated the clinical usefulness of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with suspected AIP before treatment. From September 2008 to July 2016, 53 patients with suspected AIP at National Taiwan University Hospital had PET/CT prior to therapy to exclude malignancy and evaluate the extent of inflammation. Their scans were compared with those from 61 PC patients. PET imaging features were analyzed using logistic regression. Significant differences in pancreatic tumor uptake morphology, maximum standardized uptake value, high-order primary tumor texture feature (i.e. high-gray level zone emphasis value), and numbers and location of extrapancreatic foci were found between AIP and PC. Using the prediction model, the area under curve of receiver-operator curve was 0.95 (P?

SUBMITTER: Cheng MF 

PROVIDER: S-EPMC5827761 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Clinical Utility of FDG PET/CT in Patients with Autoimmune Pancreatitis: a Case-Control Study.

Cheng Mei-Fang MF   Guo Yue Leon YL   Yen Ruoh-Fang RF   Chen Yi-Chieh YC   Ko Chi-Lun CL   Tien Yu-Wen YW   Liao Wei-Chih WC   Liu Chia-Ju CJ   Wu Yen-Wen YW   Wang Hsiu-Po HP  

Scientific reports 20180226 1


Autoimmune pancreatitis (AIP) shares overlapping clinical features with pancreatic cancer (PC). Importantly, treatment of the two conditions is different. We investigated the clinical usefulness of <sup>18</sup>F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with suspected AIP before treatment. From September 2008 to July 2016, 53 patients with suspected AIP at National Taiwan University Hospital had PET/CT prior to therapy to exclude malignancy a  ...[more]

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