Carbohydrate inhibitors of cholera toxin.
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ABSTRACT:
SUBMITTER: Kumar V
PROVIDER: S-EPMC5827775 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Carbohydrate inhibitors of cholera toxin.
Kumar Vajinder V Turnbull W Bruce WB
Beilstein journal of organic chemistry 20180221
Cholera is a diarrheal disease caused by a protein toxin released by <i>Vibrio cholera</i> in the host's intestine. The toxin enters intestinal epithelial cells after binding to specific carbohydrates on the cell surface. Over recent years, considerable effort has been invested in developing inhibitors of toxin adhesion that mimic the carbohydrate ligand, with particular emphasis on exploiting the multivalency of the toxin to enhance activity. In this review we introduce the structural features ...[more]
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