Ontology highlight
ABSTRACT:
SUBMITTER: Ren G
PROVIDER: S-EPMC5828172 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Ren Gang G Jin Wenfei W Cui Kairong K Rodrigez Joseph J Hu Gangqing G Zhang Zhiying Z Larson Daniel R DR Zhao Keji K
Molecular cell 20170901 6
Recent studies indicate that even a homogeneous population of cells display heterogeneity in gene expression and response to environmental stimuli. Although promoter structure critically influences the cell-to-cell variation of gene expression in bacteria and lower eukaryotes, it remains unclear what controls the gene expression noise in mammals. Here we report that CTCF decreases cell-to-cell variation of expression by stabilizing enhancer-promoter interaction. We show that CTCF binding sites a ...[more]