Ontology highlight
ABSTRACT:
SUBMITTER: Farley-Barnes KI
PROVIDER: S-EPMC5828527 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Farley-Barnes Katherine I KI McCann Kathleen L KL Ogawa Lisa M LM Merkel Janie J Surovtseva Yulia V YV Baserga Susan J SJ
Cell reports 20180201 7
Ribosome biogenesis is a highly regulated, essential cellular process. Although studies in yeast have established some of the biological principles of ribosome biogenesis, many of the intricacies of its regulation in higher eukaryotes remain unknown. To understand how ribosome biogenesis is globally integrated in human cells, we conducted a genome-wide siRNA screen for regulators of nucleolar number. We found 139 proteins whose depletion changed the number of nucleoli per nucleus from 2-3 to onl ...[more]