Ontology highlight
ABSTRACT:
SUBMITTER: Di Gennaro A
PROVIDER: S-EPMC5828611 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Di Gennaro Antonio A Araújo Ana Carolina AC Busch Albert A Jin Hong H Wågsäter Dick D Vorkapic Emina E Caidahl Kenneth K Eriksson Per P Samuelsson Bengt B Maegdefessel Lars L Haeggström Jesper Z JZ
Proceedings of the National Academy of Sciences of the United States of America 20180205 8
Cysteinyl-leukotrienes (cys-LTs) are 5-lipoxygenase-derived lipid mediators involved in the pathogenesis and progression of inflammatory disorders, in particular asthma. We have previously found evidence linking these mediators to increased levels of proteolytic enzymes in tissue specimens of human abdominal aortic aneurysm (AAA). Here we show that antagonism of the CysLT1 receptor by montelukast, an established antiasthma drug, protects against a strong aorta dilatation (>50% increase = aneurys ...[more]