Ontology highlight
ABSTRACT:
SUBMITTER: Koreman E
PROVIDER: S-EPMC5828965 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Koreman Elijah E Sun Xiaowei X Lu Q Richard QR
Molecular and cellular neurosciences 20171215
Oligodendrocytes are essential for the development, function, and health of the vertebrate central nervous system. These cells maintain axon myelination to ensure saltatory propagation of action potentials. Oligodendrocyte develops from neural progenitor cells, in a step-wise process that involves oligodendrocyte precursor specification, proliferation, and differentiation. The lineage progression requires coordination of transcriptional and epigenetic circuits to mediate the stage-specific intri ...[more]