Ontology highlight
ABSTRACT:
SUBMITTER: Tong Y
PROVIDER: S-EPMC5829016 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Tong Yixin Y Park Sohyun S Wu Di D Harris Thurl E TE Moskaluk Christopher A CA Brautigan David L DL Fu Zheng Z
FEBS letters 20180208 4
Glycogen synthase kinase 3β (GSK-3β) is a pivotal signaling node that regulates a myriad of cellular functions and is deregulated in many pathological conditions, making it an attractive therapeutic target. Inhibitory Ser-9 phosphorylation of GSK3β by AKT is an important mechanism for negative regulation of GSK3β activity upon insulin stimulation. Here, we report that Thr-7 and Thr-8 residues located in the AKT/PKB substrate consensus sequence on GSK3β are essential for insulin-stimulated Ser-9 ...[more]