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Streptococcus agalactiae Inhibits Candida albicans Hyphal Development and Diminishes Host Vaginal Mucosal TH17 Response.

ABSTRACT: Streptococcus agalactiae and Candida albicans often co-colonize the female genital tract, and under certain conditions induce mucosal inflammation. The role of the interaction between the two organisms in candidal vaginitis is not known. In this study, we found that co-infection with S. agalactiae significantly attenuated the hyphal development of C. albicans, and that EFG1-Hwp1 signal pathway of C. albicans was involved in this process. In a mouse model of vulvovaginal candidiasis (VVC), the fungal burden and the levels of pro-inflammatory cytokines, IL-1?, IL-6 and TNF-? showed a increase on co-infection with S. agalactiae, while the level of TH17 T cells and IL-17 in the cervicovaginal lavage fluid were significantly decreased. Our results indicate that S. agalactiae inhibits C. albicans hyphal development by downregulating the expression of EFG1-Hwp1. The interaction between S. agalactiae and C. albicans may attenuate host vaginal mucosal TH17 immunity and contribute to mucosal colonization by C. albicans.

SUBMITTER: Yu XY 

PROVIDER: S-EPMC5829043 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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<i>Streptococcus agalactiae</i> Inhibits <i>Candida albicans</i> Hyphal Development and Diminishes Host Vaginal Mucosal TH17 Response.

Yu Xiao-Yu XY   Fu Fei F   Kong Wen-Na WN   Xuan Qian-Kun QK   Wen Dong-Hua DH   Chen Xiao-Qing XQ   He Yong-Ming YM   He Li-Hua LH   Guo Jian J   Zhou Ai-Ping AP   Xi Yang-Hong YH   Ni Li-Jun LJ   Yao Yu-Feng YF   Wu Wen-Juan WJ  

Frontiers in microbiology 20180223

<i>Streptococcus agalactiae</i> and <i>Candida albicans</i> often co-colonize the female genital tract, and under certain conditions induce mucosal inflammation. The role of the interaction between the two organisms in candidal vaginitis is not known. In this study, we found that co-infection with <i>S. agalactiae</i> significantly attenuated the hyphal development of <i>C. albicans</i>, and that <i>EFG1</i>-Hwp1 signal pathway of <i>C. albicans</i> was involved in this process. In a mouse model  ...[more]

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