Human Pluripotent Stem Cell-Derived Cardiac Tissue-like Constructs for Repairing the Infarcted Myocardium.
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SUBMITTER: Li J
PROVIDER: S-EPMC5829319 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
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Human Pluripotent Stem Cell-Derived Cardiac Tissue-like Constructs for Repairing the Infarcted Myocardium.
Li Junjun J Minami Itsunari I Shiozaki Motoko M Yu Leqian L Yajima Shin S Miyagawa Shigeru S Shiba Yuji Y Morone Nobuhiro N Fukushima Satsuki S Yoshioka Momoko M Li Sisi S Qiao Jing J Li Xin X Wang Lin L Kotera Hidetoshi H Nakatsuji Norio N Sawa Yoshiki Y Chen Yong Y Liu Li L
Stem cell reports 20171026 5
High-purity cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) are promising for drug development and myocardial regeneration. However, most hiPSC-derived CMs morphologically and functionally resemble immature rather than adult CMs, which could hamper their application. Here, we obtained high-quality cardiac tissue-like constructs (CTLCs) by cultivating hiPSC-CMs on low-thickness aligned nanofibers made of biodegradable poly(D,L-lactic-co-glycolic acid) polymer. We s ...[more]
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