Ontology highlight
ABSTRACT:
SUBMITTER: Kasemeier-Kulesa JC
PROVIDER: S-EPMC5829509 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Kasemeier-Kulesa Jennifer C JC Romine Morgan H MH Morrison Jason A JA Bailey Caleb M CM Welch Danny R DR Kulesa Paul M PM
Biology open 20180111 1
Melanoma pathogenesis from normal neural crest-derived melanocytes is often fatal due to aggressive cell invasion throughout the body. The identification of signals that reprogram de-differentiated, metastatic melanoma cells to a less aggressive and stable phenotype would provide a novel strategy to limit disease progression. In this study, we identify and test the function of developmental signals within the chick embryonic neural crest microenvironment to reprogram and sustain the transition o ...[more]