Ontology highlight
ABSTRACT:
SUBMITTER: Ji X
PROVIDER: S-EPMC5829739 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Ji Xinjun X Humenik Jesse J Yang Daphne D Liebhaber Stephen A SA
Nucleic acids research 20180201 4
The PolyC binding proteins (PCBPs) impact alternative splicing of a subset of mammalian genes that are enriched in basic cellular functions. Here, we focus our analysis on PCBP-controlled cassette exon-splicing within the cell cycle control regulator cyclin-dependent kinase-2 (CDK2) transcript. We demonstrate that PCBP binding to a C-rich polypyrimidine tract (PPT) preceding exon 5 of the CDK2 transcript enhances cassette exon inclusion. This splice enhancement is U2AF65-independent and predomin ...[more]