Opposite regulation of inhibition by adult-born granule cells during implicit versus explicit olfactory learning.

ABSTRACT: Both passive exposure and active learning through reinforcement enhance fine sensory discrimination abilities. In the olfactory system, this enhancement is thought to occur partially through the integration of adult-born inhibitory interneurons resulting in a refinement of the representation of overlapping odorants. Here, we identify in mice a novel and unexpected dissociation between passive and active learning at the level of adult-born granule cells. Specifically, while both passive and active learning processes augment neurogenesis, adult-born cells differ in their morphology, functional coupling and thus their impact on olfactory bulb output. Morphological analysis, optogenetic stimulation of adult-born neurons and mitral cell recordings revealed that passive learning induces increase

SUBMITTER: Mandairon N 

PROVIDER: S-EPMC5829916 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature