Ontology highlight
ABSTRACT:
SUBMITTER: Lin Y
PROVIDER: S-EPMC5830358 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Lin Ying Y Sui Liu-Cai LC Wu Rong-Hua RH Ma Ru-Jun RJ Fu Hai-Yan HY Xu Juan-Juan JJ Qiu Xu-Hua XH Chen Li L
The Journal of reproduction and development 20171216 1
Brusatol, a quassinoid isolated from the fruit of Bruceajavanica, has recently been shown to inhibit nuclear factor erythroid 2-related factor 2 (Nrf2) via Keap1-dependent ubiquitination and proteasomal degradation or protein synthesis. Nrf2 is a transcription factor that regulates the cellular defense response. Most studies have focused on the effects of Nrf2 in tumor development. Here, the critical roles of Nrf2 in mouse early embryonic development were investigated. We found that brusatol tre ...[more]