Ontology highlight
ABSTRACT:
SUBMITTER: Higuchi C
PROVIDER: S-EPMC5830360 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Higuchi Chika C Shimizu Natsumi N Shin Seung-Wook SW Morita Kohtaro K Nagai Kouhei K Anzai Masayuki M Kato Hiromi H Mitani Tasuku T Yamagata Kazuo K Hosoi Yoshihiko Y Miyamoto Kei K Matsumoto Kazuya K
The Journal of reproduction and development 20171207 1
Maternal RNA/protein degradation and zygotic genome activation (ZGA), occurring during maternal-to-zygotic transition (MZT), are the first essential events for the development of pre-implantation embryos. Previously, we have shown the importance of the ubiquitin-proteasome system (UPS) for initiation of minor ZGA at the 1-cell stage of mouse embryos. However, little is known about the mechanism of involvement of the UPS-degraded maternal proteins in ZGA. In this study, we investigated the effect ...[more]