Melphalan 140 mg/m² or 200 mg/m² for autologous transplantation in myeloma: results from the Collaboration to Collect Autologous Transplant Outcomes in Lymphoma and Myeloma (CALM) study. A report by the EBMT Chronic Malignancies Working Party.

ABSTRACT: Melphalan at a dose of 200 mg/m² is standard conditioning prior to autologous hematopoietic stem cell transplantation for multiple myeloma, but a dose of 140 mg/m² is often used in clinical practice in patients perceived to be at risk of excess toxicity. To determine whether melphalan 200 mg/m² and melphalan 140 mg/m² are equally effective and tolerable in clinically relevant patient subgroups we analyzed 1964 first single autologous transplantation episodes using a series of Cox proportional-hazards models. Overall survival, progression-free survival, cumulative incidence of relapse, non-relapse mortality, hematopoietic recovery and second primary malignancy rates were not significantly different between the melphalan 140 mg/m² (n=245) and melphalan 200 mg/m² (n=1719) groups. Multivariable subgroup analysis showed that disease status at transplantation interacted with overall survival, progression-free survival, and cumulative incidence of relapse, with a significant advantage associated with melphalan 200 mg/m² in patients transplanted in less than partial response (adjusted hazard ratios for melphalan 200 mg/m²versus melphalan 140 mg/m²: 0.5, 0.54, and 0.56). In contrast, transplantation in very good partial or complete response significantly favored melphalan 140 mg/m² for overall survival (adjusted hazard ratio: 2.02). Age, renal function, prior proteasome inhibitor treatment, gender, or Karnofsky score did not interact with overall/progression-free survival or relapse rate in the melphalan dose groups. There were no significant survival or relapse rate differences between melphalan 200 mg/m² and melphalan 140 mg/m² patients with high-risk or standard-risk chromosomal abnormalities. In conclusion, remission status at the time of transplantation may favor the use of melphalan 200 mg/m² or melphalan 140 mg/m² for key transplant outcomes (NCT01362972).

SUBMITTER: Auner HW 

PROVIDER: S-EPMC5830386 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature