Ontology highlight
ABSTRACT:
SUBMITTER: Kolenda C
PROVIDER: S-EPMC5830412 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Kolenda Caroline C Ortiz Jennifer J Pelzl Marina M Norell Sarina S Schmeiser Verena V Lechner Johannes J
Nature communications 20180228 1
Kinetochores that are not attached to microtubules prevent chromosome missegregation via the spindle assembly checkpoint. We show that they also promote their own capturing. Similar to what governs the localization of spindle assembly checkpoint proteins, the phosphorylation of Spc105 by Mps1 allows unattached kinetochores to sequester Stu1 in cooperation with Slk19. The withdrawal of Stu1, a CLASP essential for spindle integrity, from microtubules and attached kinetochores disrupts the organiza ...[more]