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A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative.

ABSTRACT: A facile synthetic method was developed for a novel acid-sensitive camptothecin norcantharidin acid ester derivative I. The total yield can reach 71%. This method provides several advantages, including high yield and simple working procedure for the synthesis of analogues. The new synthetic compound I has been shown to exhibit better solubility and similar activity against tumour cell lines.

SUBMITTER: Zhao C

PROVIDER: S-EPMC5830714 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative.

Zhao Changkuo C Wang Xianheng X Yang Fuhong F Gao Lei L Wang Yuhe Y

Royal Society open science 20180214 2

A facile synthetic method was developed for a novel acid-sensitive camptothecin norcantharidin acid ester derivative I. The total yield can reach 71%. This method provides several advantages, including high yield and simple working procedure for the synthesis of analogues. The new synthetic compound I has been shown to exhibit better solubility and similar activity against tumour cell lines. ...[more]

PMID: 29515825

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