Ontology highlight
ABSTRACT:
SUBMITTER: Thurner M
PROVIDER: S-EPMC5831005 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Thurner Matthias M Shenhav Liraz L Wesolowska-Andersen Agata A Bennett Amanda J AJ Barrett Amy A Gloyn Anna L AL McCarthy Mark I MI Beer Nicola L NL Efrat Shimon S
Stem cell reports 20171101 5
Current in vitro islet differentiation protocols suffer from heterogeneity and low efficiency. Induced pluripotent stem cells (iPSCs) derived from pancreatic beta cells (BiPSCs) preferentially differentiate toward endocrine pancreas-like cells versus those from fibroblasts (FiPSCs). We interrogated genome-wide open chromatin in BiPSCs and FiPSCs via ATAC-seq and identified ∼8.3k significant, differential open chromatin sites (DOCS) between the two iPSC subtypes (false discovery rate [FDR] < 0.05 ...[more]