Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac Surgery: A Randomized Clinical Trial.

ABSTRACT:

Importance

Postoperative delirium occurs in 10% to 60% of elderly patients having major surgery and is associated with longer hospital stays, increased hospital costs, and 1-year mortality. Emerging literature suggests that dexmedetomidine sedation in critical care units is associated with reduced incidence of delirium. However, intraoperative use of dexmedetomidine for prevention of delirium has not been well studied.

Objective

To evaluate whether an intraoperative infusion of dexmedetomidine reduces postoperative delirium.

Design, setting, and participants

This study was a multicenter, double-blind, randomized, placebo-controlled trial that randomly assigned patients to dexmedetomidine or saline placebo infused during surgery and for 2 hours in the recovery room. Pa

SUBMITTER: Deiner S 

PROVIDER: S-EPMC5831461 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature