Role and Possible Mechanisms of Sirt1 in Depression.
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ABSTRACT:
SUBMITTER: Lu G
PROVIDER: S-EPMC5831942 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Role and Possible Mechanisms of Sirt1 in Depression.
Lu Guofang G Li Jianguo J Zhang Hongmei H Zhao Xin X Yan Liang-Jun LJ Yang Xiaorong X
Oxidative medicine and cellular longevity 20180131
Depression is a common, devastating illness. Due to complicated causes and limited treatments, depression is still a major problem that plagues the world. Silent information regulator 1 (Sirt1) is a deacetylase at the consumption of NAD<sup>+</sup> and is involved in gene silencing, cell cycle, fat and glucose metabolism, cellular oxidative stress, and senescence. Sirt1 has now become a critical therapeutic target for a number of diseases. Recently, a genetic study has received considerable atte ...[more]
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