Ontology highlight
ABSTRACT:
SUBMITTER: Hallan S
PROVIDER: S-EPMC5832558 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Hallan Stein S Afkarian Maryam M Zelnick Leila R LR Kestenbaum Bryan B Sharma Shoba S Saito Rintaro R Darshi Manjula M Barding Gregory G Raftery Daniel D Ju Wenjun W Kretzler Matthias M Sharma Kumar K de Boer Ian H IH
EBioMedicine 20171031
Chronic kidney disease (CKD) is a public health problem with very high prevalence and mortality. Yet, there is a paucity of effective treatment options, partly due to insufficient knowledge of underlying pathophysiology. We combined metabolomics (GCMS) with kidney gene expression studies to identify metabolic pathways that are altered in adults with non-diabetic stage 3-4 CKD versus healthy adults. Urinary excretion rate of 27 metabolites and plasma concentration of 33 metabolites differed signi ...[more]