Ontology highlight
ABSTRACT:
SUBMITTER: Cho JH
PROVIDER: S-EPMC5832765 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Cho Jang Hwan JH Okuma Atsushi A Al-Rubaye Dalal D Intisar Ejaj E Junghans Richard P RP Wong Wilson W WW
Scientific reports 20180301 1
Axl is a tyrosine kinase receptor that is commonly overexpressed in many cancers. As such, Axl represents an attractive therapeutic target. The transfer of engineered T cell expressing chimeric antigen receptor (CAR) is an exciting cancer therapeutic approach that shows high efficacy against cancers in clinical trials, especially for B cell malignancies. Furthermore, recently developed synthetic Notch (synNotch) receptor has demonstrated potential in enhancing the specificity of CAR T cell thera ...[more]