Ontology highlight
ABSTRACT:
SUBMITTER: Milic D
PROVIDER: S-EPMC5832771 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Milić Dalibor D Dick Markus M Mulnaes Daniel D Pfleger Christopher C Kinnen Anna A Gohlke Holger H Groth Georg G
Scientific reports 20180301 1
Synthetic peptides derived from ethylene-insensitive protein 2 (EIN2), a central regulator of ethylene signalling, were recently shown to delay fruit ripening by interrupting protein-protein interactions in the ethylene signalling pathway. Here, we show that the inhibitory peptide NOP-1 binds to the GAF domain of ETR1 - the prototype of the plant ethylene receptor family. Site-directed mutagenesis and computational studies reveal the peptide interaction site and a plausible molecular mechanism f ...[more]