Ontology highlight
ABSTRACT:
SUBMITTER: Massonneau J
PROVIDER: S-EPMC5832969 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Massonneau Julien J Ouellet Camille C Lucien Fabrice F Dubois Claire M CM Tyler Jessica J Boissonneault Guylain G
FEBS open bio 20180216 3
Conditions leading to unrepaired DNA double-stranded breaks are potent inducers of genetic instability. Systemic conditions may lead to fluctuation of hydrogen ions in the cellular microenvironment, and we show that small variations in extracellular pH, termed suboptimal pHe, can decrease the efficiency of DNA repair in the absence of intracellular pH variation. Recovery from bleomycin-induced DNA double-stranded breaks in fibroblasts proceeded less efficiently at suboptimal pHe values ranging f ...[more]