ZEB1 confers chemotherapeutic resistance to breast cancer by activating ATM.
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ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC5833408 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
ZEB1 confers chemotherapeutic resistance to breast cancer by activating ATM.
Zhang Xiang X Zhang Zhen Z Zhang Qing Q Zhang Quansheng Q Sun Peiqing P Xiang Rong R Ren Guosheng G Yang Shuang S
Cell death & disease 20180119 2
Although zinc finger E-box binding homeobox 1 (ZEB1) has been identified as a key factor in the regulation of breast cancer differentiation and metastasis, its potential role in modulating tumor chemoresistance has not been fully understood. Here, through the study of specimens from a large cohort of human breast cancer subjects, we showed that patients with tumors that expressed high levels of ZEB1 responded poorly to chemotherapy. Moreover, ZEB1 expression was positively correlated with expres ...[more]
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