Ontology highlight
ABSTRACT:
SUBMITTER: Machado-Neto JA
PROVIDER: S-EPMC5833553 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Machado-Neto João Agostinho JA Fenerich Bruna Alves BA Scopim-Ribeiro Renata R Eide Christopher A CA Coelho-Silva Juan Luiz JL Dechandt Carlos Roberto Porto CRP Fernandes Jaqueline Cristina JC Rodrigues Alves Ana Paula Nunes APN Scheucher Priscila Santos PS Simões Belinda Pinto BP Alberici Luciane Carla LC de Figueiredo Pontes Lorena Lôbo LL Tognon Cristina E CE Druker Brian J BJ Rego Eduardo Magalhães EM Traina Fabiola F
Cell death & disease 20180222 3
The recurrent gain-of-function JAK2<sup>V617F</sup> mutation confers growth factor-independent proliferation for hematopoietic cells and is a major contributor to the pathogenesis of myeloproliferative neoplasms (MPN). The lack of complete response in most patients treated with the JAK1/2 inhibitor ruxolitinib indicates the need for identifying novel therapeutic strategies. Metformin is a biguanide that exerts selective antineoplastic activity in hematological malignancies. In the present study, ...[more]