Dataset Information

Adjuvant Chemotherapy vs Postoperative Observation Following Preoperative Chemoradiotherapy and Resection in Gastroesophageal Cancer: A Propensity Score-Matched Analysis.

ABSTRACT:

Importance

Distant recurrence following preoperative chemoradiotherapy and resection in patients with gastroesophageal adenocarcinoma is common. Adjuvant chemotherapy may improve survival.

Objective

To compare adjuvant chemotherapy with postoperative observation following preoperative chemoradiotherapy and resection in patients with gastroesophageal adenocarcinoma.

Design, setting, and participants

Propensity score-matched analysis using the National Cancer Database. We included adult patients who received a diagnosis between 2006 and 2013 of clinical stage T1N1-3M0 or T2-4N0-3M0 adenocarcinoma of the distal esophagus or gastric cardia who were treated with preoperative chemoradiotherapy and curative-intent resection. Patients receiving adjuvant chemotherapy were matched by propensity score to patients undergoing postoperative observation.

Exposures

Adjuvant chemotherapy and postoperative observation.

Main outcomes and measures

Overall survival.

Results

We identified 10?086 patients (8840 [88%] male; mean [SD] age, 61 [9.5] years), 9272 in the postoperative observation group and 814 in the adjuvant chemotherapy group. Patients receiving adjuvant chemotherapy were younger (18-54 years: 252 [31%] vs 1989 [21%]; P?2 weeks: 94 [13%] vs 1589 [20%]; P?Conclusions and relevanceFor patients with locally advanced gastroesophageal adenocarcinoma treated with preoperative chemoradiotherapy and resection, adjuvant chemotherapy was associated with improved overall survival. Our findings have important implications for the postoperative treatment of this patient group for which few data are available.

SUBMITTER: Mokdad AA

PROVIDER: S-EPMC5833647 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Publications

Adjuvant Chemotherapy vs Postoperative Observation Following Preoperative Chemoradiotherapy and Resection in Gastroesophageal Cancer: A Propensity Score-Matched Analysis.

Mokdad Ali A AA Yopp Adam C AC Polanco Patricio M PM Mansour John C JC Reznik Scott I SI Heitjan Daniel F DF Choti Michael A MA Minter Rebecca R RR Wang Sam C SC Porembka Matthew R MR

JAMA oncology 20180101 1

<h4>Importance</h4>Distant recurrence following preoperative chemoradiotherapy and resection in patients with gastroesophageal adenocarcinoma is common. Adjuvant chemotherapy may improve survival.<h4>Objective</h4>To compare adjuvant chemotherapy with postoperative observation following preoperative chemoradiotherapy and resection in patients with gastroesophageal adenocarcinoma.<h4>Design, setting, and participants</h4>Propensity score-matched analysis using the National Cancer Database. We inc ...[more]

PMID: 28975352

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Dataset Information

Adjuvant Chemotherapy vs Postoperative Observation Following Preoperative Chemoradiotherapy and Resection in Gastroesophageal Cancer: A Propensity Score-Matched Analysis.

Importance

Objective

Design, setting, and participants

Exposures

Main outcomes and measures

Results

Publications

Adjuvant Chemotherapy vs Postoperative Observation Following Preoperative Chemoradiotherapy and Resection in Gastroesophageal Cancer: A Propensity Score-Matched Analysis.

Similar Datasets

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