Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC5833759 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Zhang Shaoyi S Stoll Gautier G Pedro José Manuel Bravo San JMBS Sica Valentina V Sauvat Allan A Obrist Florine F Kepp Oliver O Li Yousheng Y Maiuri Luigi L Zamzami Naoufal N Kroemer Guido G
Cell death & disease 20180207 2
Cystic Fibrosis (CF) due to the ΔF508 mutation of cystic fibrosis transmembrane conductance regulator (CFTR) can be treated with a combination of cysteamine and Epigallocatechin gallate (EGCG). Since ECGC is not a clinically approved drug, we attempted to identify other compounds that might favourably interact with cysteamine to induce autophagy and thus rescuing the function of ΔF508 CFTR as a chloride channel in the plasma membrane. For this, we screened a compound library composed by chemical ...[more]