Ontology highlight
ABSTRACT:
SUBMITTER: Allocati N
PROVIDER: S-EPMC5833873 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Allocati Nerino N Masulli Michele M Di Ilio Carmine C Federici Luca L
Oncogenesis 20180124 1
Glutathione transferase classical GSH conjugation activity plays a critical role in cellular detoxification against xenobiotics and noxious compounds as well as against oxidative stress. However, this feature is also exploited by cancer cells to acquire drug resistance and improve their survival. As a result, various members of the family were found overexpressed in a number of different cancers. Moreover several GST polymorphisms, ranging from null phenotypes to point mutations, were detected i ...[more]