Ontology highlight
ABSTRACT:
SUBMITTER: Wages NA
PROVIDER: S-EPMC5834099 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Wages N A NA Slingluff C L CL Petroni G R GR
Annals of oncology : official journal of the European Society for Medical Oncology 20170401 4
<h4>Background</h4>In recent years, investigators have asserted that the 3 + 3 design lacks flexibility, making its use in modern early-phase trial settings, such as combinations and/or biological agents, inefficient. More innovative approaches are required to address contemporary research questions, such as those posed in trials involving immunotherapies.<h4>Design</h4>We describe the implementation of an adaptive design for identifying an optimal treatment regimen, defined by low toxicity and ...[more]