A new era of studying p53-mediated transcription activation.
Ontology highlight
ABSTRACT:
SUBMITTER: Liu WL
PROVIDER: S-EPMC5834226 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
A new era of studying p53-mediated transcription activation.
Liu Wei-Li WL Coleman Robert A RA Singh Sameer K SK
Transcription 20171004 2
To prevent tumorigenesis, p53 stimulates transcription by facilitating the recruitment of the transcription machinery on target gene promoters. Cryo-Electron Microscopy studies on p53-bound RNA Polymerase II (Pol II) reveal that p53 structurally regulates Pol II to affect its DNA binding and elongation, providing new insights into p53-mediated transcriptional regulation. ...[more]
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