Ontology highlight
ABSTRACT:
SUBMITTER: Szuperak M
PROVIDER: S-EPMC5834245 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Szuperak Milan M Churgin Matthew A MA Borja Austin J AJ Raizen David M DM Fang-Yen Christopher C Kayser Matthew S MS
eLife 20180209
Sleep during development is involved in refining brain circuitry, but a role for sleep in the earliest periods of nervous system elaboration, when neurons are first being born, has not been explored. Here we identify a sleep state in <i>Drosophila</i> larvae that coincides with a major wave of neurogenesis. Mechanisms controlling larval sleep are partially distinct from adult sleep: octopamine, the <i>Drosophila</i> analog of mammalian norepinephrine, is the major arousal neuromodulator in larva ...[more]