Ontology highlight
ABSTRACT:
SUBMITTER: Xu Y
PROVIDER: S-EPMC5834470 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Xu Yan Y Ikeda Satoshi S Sumida Kentaro K Yamamoto Ryusuke R Tanaka Hiroki H Minato Nagahiro N
Nature communications 20180302 1
Chronic myelogenous leukemia (CML) caused by hematopoietic stem cells expressing the Bcr-Abl fusion gene may be controlled by Bcr-Abl tyrosine kinase inhibitors (TKIs). However, CML-initiating cells are resistant to TKIs and may persist as minimal residual disease. We demonstrate that mice deficient in Sipa1, which encodes Rap1 GTPase-activating protein, rarely develop CML upon transfer of primary hematopoietic progenitor cells (HPCs) expressing Bcr-Abl, which cause lethal CML disease in wild-ty ...[more]