Ontology highlight
ABSTRACT:
SUBMITTER: Huynh KW
PROVIDER: S-EPMC5834491 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Nature communications 20180302 1
Na<sup>+</sup>-coupled acid-base transporters play essential roles in human biology. Their dysfunction has been linked to cancer, heart, and brain disease. High-resolution structures of mammalian Na<sup>+</sup>-coupled acid-base transporters are not available. The sodium-bicarbonate cotransporter NBCe1 functions in multiple organs and its mutations cause blindness, abnormal growth and blood chemistry, migraines, and impaired cognitive function. Here, we have determined the structure of the membr ...[more]