Ontology highlight
ABSTRACT:
SUBMITTER: Evans MA
PROVIDER: S-EPMC5834596 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Evans Megan A MA Kim Hyun Ah HA Ling Yeong Hann YH Uong Sandy S Vinh Antony A De Silva T Michael TM Arumugam Thiruma V TV Clarkson Andrew N AN Zosky Graeme R GR Drummond Grant R GR Broughton Brad R S BRS Sobey Christopher G CG
Neuromolecular medicine 20180223 1
Acute inflammation can exacerbate brain injury after ischemic stroke. Beyond its well-characterized role in calcium metabolism, it is becoming increasingly appreciated that the active form of vitamin D, 1,25-dihydroxyvitamin D<sub>3</sub> (1,25-VitD<sub>3</sub>), has potent immunomodulatory properties. Here, we aimed to determine whether 1,25-VitD<sub>3</sub> supplementation could reduce subsequent brain injury and associated inflammation after ischemic stroke. Male C57Bl6 mice were randomly ass ...[more]