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Immune parameters to p67C antigen adjuvanted with ISA206VG correlate with protection against East Coast fever.

ABSTRACT: East Coast fever (ECF) is a lymphoproliferative disease caused by the tick-transmitted protozoan parasite Theileria parva. ECF is one of the most serious cattle tick-borne diseases in Sub-Saharan Africa. We have previously demonstrated that three doses of the C-terminal part of the sporozoite protein p67 (p67C) adjuvanted with ISA206VG confers partial protection against ECF at a herd level. We have tested the efficacy of two doses of this experimental vaccine, as reducing the vaccination regimen would facilitate its deployment in the field. We reconfirm that three antigen doses gave a significant level of protection to severe disease (46%, ECF score?

SUBMITTER: Lacasta A

PROVIDER: S-EPMC5835154 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Immune parameters to p67C antigen adjuvanted with ISA206VG correlate with protection against East Coast fever.

Lacasta Anna A Mwalimu Stephen S Kibwana Elisabeth E Saya Rosemary R Awino Elias E Njoroge Thomas T Poole Jane J Ndiwa Nicholas N Pelle Roger R Nene Vishvanath V Steinaa Lucilla L

Vaccine 20180301 11

East Coast fever (ECF) is a lymphoproliferative disease caused by the tick-transmitted protozoan parasite Theileria parva. ECF is one of the most serious cattle tick-borne diseases in Sub-Saharan Africa. We have previously demonstrated that three doses of the C-terminal part of the sporozoite protein p67 (p67C) adjuvanted with ISA206VG confers partial protection against ECF at a herd level. We have tested the efficacy of two doses of this experimental vaccine, as reducing the vaccination regimen ...[more]

PMID: 29429808

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