Ontology highlight
ABSTRACT:
SUBMITTER: Sinnett SE
PROVIDER: S-EPMC5835264 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Sinnett Sarah E SE Brenman Jay E JE
Experientia supplementum (2012) 20160101
In the fruit fly, Drosophila melanogaster, mono-allelic expression of AMPK-α, -β, and -γ yields a single heterotrimeric energy sensor that regulates cellular and whole-body energetic homeostasis. The genetic simplicity of Drosophila, with only a single gene for each subunit, makes the fruit fly an appealing organism for elucidating the effects of AMPK mutations on signaling pathways and phenotypes. In addition, Drosophila presents researchers with an opportunity to use straightforward genetic ap ...[more]