Genomic Activation of PPARG Reveals a Candidate Therapeutic Axis in Bladder Cancer.
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ABSTRACT:
SUBMITTER: Goldstein JT
PROVIDER: S-EPMC5835321 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
Genomic Activation of <i>PPARG</i> Reveals a Candidate Therapeutic Axis in Bladder Cancer.
Goldstein Jonathan T JT Berger Ashton C AC Shih Juliann J Duke Fujiko F FF Furst Laura L Kwiatkowski David J DJ Cherniack Andrew D AD Meyerson Matthew M Strathdee Craig A CA
Cancer research 20170918 24
The <i>PPARG</i> gene encoding the nuclear receptor PPARγ is activated in bladder cancer, either directly by gene amplification or mutation, or indirectly by mutation of the <i>RXRA</i> gene, which encodes the heterodimeric partner of PPARγ. Here, we show that activating alterations of <i>PPARG</i> or <i>RXRA</i> lead to a specific gene expression signature in bladder cancers. Reducing PPARG activity, whether by pharmacologic inhibition or genetic ablation, inhibited proliferation of PPARG-activ ...[more]
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