Albusnodin: an acetylated lasso peptide from Streptomyces albus.
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ABSTRACT:
SUBMITTER: Zong C
PROVIDER: S-EPMC5835390 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Albusnodin: an acetylated lasso peptide from Streptomyces albus.
Zong Chuhan C Cheung-Lee Wai Ling WL Elashal Hader E HE Raj Monika M Link A James AJ
Chemical communications (Cambridge, England) 20180201 11
We describe a lasso peptide, albusnodin, that is post-translationally modified with an acetyl group, the first example of a lasso peptide with this modification. Using heterologous expression, we further show that the acetyltransferase colocalized with the albusnodin gene cluster is required for the biosynthesis of this lasso peptide. This type of lasso peptide is widespread in Actinobacteria with 44 examples found in currently sequenced genomes. ...[more]
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