Inflammation and coronary artery calcification in South Asians: The Mediators of Atherosclerosis in South Asians Living in America (MASALA) study.

ABSTRACT: BACKGROUND AND AIMS:Inflammatory biomarkers and adipocytokines (IBA) may contribute to atherosclerosis by promoting vascular inflammation. The association between IBA and coronary artery calcium (CAC), a marker of subclinical atherosclerosis, is not well defined in South Asians (SA). We hypothesized that IBA (high sensitivity C-reactive protein [hsCRP], tumor necrosis factor alpha [TNF-?], adiponectin, and leptin) were independently associated with and improved discrimination of CAC among SA. METHODS:We analyzed IBA and CAC among participants in the prospective Mediators of Atherosclerosis in South Asians Living in America (MASALA) study. We used logistic regression models to examine cross-sectional associations of IBA with CAC presence (CAC >0) and severity (CAC >100), and C-statistics to assess the incremental contribution of each IBA to traditional risk factors (TRF) from the AHA/ACC Pooled Cohort Equations (PCE) for discrimination of CAC. RESULTS:Among 906 participants in the MASALA study, women (n?=?420) had significantly higher levels of hsCRP, adiponectin, and leptin but lower levels of TNF-? than men (p?

SUBMITTER: Mehta A 

PROVIDER: S-EPMC5835417 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature