Relationships between Serotonin Transporter Binding in the Raphe Nuclei, Basal Ganglia, and Hippocampus with Clinical Symptoms in Cervical Dystonia: A [¹¹C]DASB Positron Emission Tomography Study.

ABSTRACT:

Purpose

Alterations of the central serotonergic system have been implicated in the pathophysiology of dystonia. In this molecular imaging study, we assessed whether altered presynaptic serotonin transporter (SERT) binding contributes to the pathophysiology of cervical dystonia (CD), concerning both motor and non-motor symptoms (NMS).

Methods

We assessed the non-displaceable binding potential (BP_ND) using the selective SERT tracer [¹¹C]DASB and positron emission tomography (PET) in 14 CD patients and 12 age- and gender-matched controls. Severity of motor symptoms was scored using the Toronto Western Spasmodic Torticollis Rating Scale and Clinical Global Impression jerks/tremor scale. NMS for depressive symptoms, anxiety, fatigue, and sleep disturbances w

SUBMITTER: Smit M 

PROVIDER: S-EPMC5835525 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature